CAS No. 796073-69-3

Molecular Formula: C38H54ClN3O10S

Description:
DM4 is an anti-tubulin agent that inhibits cell division. DM4 can be used to prepare antibody-drug conjugates. DM4 binds to tubulin at the maytansine-binding site, disrupting microtubule assembly/disassembly dynamics and inhibiting mitosis.

• Molecular Weight: 780.37
• Molecular Formula: C38H54ClN3O10S

Purity: ≥95%

Canonical SMILES:
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCC(C)(C)S)C)C)OC)(NC(=O)O2)O

InChI:
InChI=1S/C38H54ClN3O10S/c1-21-12-11-13-28(49-10)38(47)20-27(50-35(46)40-38)22(2)33-37(6,52-33)29(51-34(45)23(3)41(7)30(43)14-15-36(4,5)53)19-31(44)42(8)25-17-24(16-21)18-26(48-9)32(25)39/h11-13,17-18,22-23,27-29,33,47,53H,14-16,19-20H2,1-10H3,(H,40,46)/b13-11+,21-12+/t22-,23+,27+,28-,29+,33+,37+,38+/m1/s1

InChIKey: JFCFGYGEYRIEBE-YVLHJLIDSA-N

• Boiling Point: 943.2±65.0°C (Predicted)
• Melting Point: 185-187°C (dec.)
• Solubility: Soluble in DMSO
• Appearance: Soild powder
• Storage: Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Synonyms:
Maytansinoid DM 4; Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-; N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine; Ravtansine

More details are to be found on supplier website

Appearance	white powder
Purity	99% min
DM4 is an anti-tubulin agent that inhibits cell division.
DM4 can be used to prepare antibody drug conjugates. Maytansine (Mertansine, DM1, CAS 796073-69-3) is a tubulin Chemicalbook inhibitor that binds to the ends of microtubules and inhibits the dynamics of microtubules.
Mertansine is an antibody-conjugated maytansinoid used to overcome the systemic toxicity associated with maytansine and enhance tumor-specific delivery.