Description:
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor.
- Molecular Weight: 418.36
- Molecular Formula: C22H25Cl2N3O
Purity: >98%
Canonical SMILES:
[H+].CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.[Cl-]
InChI:
InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
InChIKey: YEJAJYAHJQIWNU-UHFFFAOYSA-N
- Melting Point: 223-225°C
- Solubility: In Vitro: DMSO : 50 mg/mL(119.51 mM;Need ultrasonic)H2O : 6.67 mg/mL(15.94 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution2.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution
- Appearance: White Solid
- Application: histamine antagonist
- Storage: 4°C, sealed storage, away from moisture* In solvent : -80°C, 6 months-20°C, 1 month (sealed storage, away from moisture)
Synonyms:
ZELASTINE HYDROCHLORIDE; AC1Q1SYE; HYDROGEN AZELASTINE CHLORIDE; AKOS026749829; DR002552
More details are to be found on supplier website
