Description:
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKKɛ with IC50 of 41 nM.
- Molecular Weight: 591.47
- Molecular Formula: C23H26IN7O2S
Purity: ≥98%
Canonical SMILES:
[H]N(CCCN(C(C1=CC=CS1)=O)[H])C2=C(I)C=NC(N([H])C3=CC(N(C(N4CCCC4)=O)[H])=CC=C3)=N2
InChI:
InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
InChIKey: VAVXGGRQQJZYBL-UHFFFAOYSA-NShipping & Storage Information
- Solubility: Soluble to 50 mg/mL in DMSO.
- Appearance: Crystalline Solid
Synonyms:
BX 795; BX795
More details are to be found on supplier website
