Description:
Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI) for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
- Molecular Weight: 447.88
- Molecular Formula: C23H23ClFNO5
Purity: ≥98%
Canonical SMILES:
CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
InChI:
InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
InChIKey: JUZYLCPPVHEVSV-LJQANCHMSA-N
- Boiling Point: 623.6±55.0 °C at 760 mmHg
- Melting Point: 93-96°C
- Solubility: In Vitro: DMSO : 250 mg/mL(558.19 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: 2.5 mg/mL (5.58 mM); Suspended solution; Need ultrasonic2.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution3.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution
- Appearance: Off-White to Pale Yellow Solid
- Application: Anti-Retroviral Agents
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
GS-9137; GS 9137; GS9137; JTK-303; JTK 303; JTK303; EVG; D06677; D 06677; D-06677
More details are to be found on supplier website
