Description:
Corynoxine is an enantiomer of Corynoxine B. It induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. By inducing autophagy, it promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. It also significantly decreased locomotor activity after oral administration to mice.
- Molecular Weight: 384.47
- Molecular Formula: C22H28N2O4
Purity: >98%
Canonical SMILES:
CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
InChI:
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1
InChIKey: DAXYUDFNWXHGBE-NRAMRBJXSA-N
- Boiling Point: 560.8±50.0°C (Predicted)
- Melting Point: 166-168°C
- Appearance: Cryst.
Synonyms:
(16E)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
More details are to be found on supplier website
