Description:
Jatrorrhizine Hydrochloride (JH), an active component of the traditional Chinese medicinal herb Coptis chinensis, inhibited the proliferation and neovascularization of C8161 human metastatic melanoma cells. The effective inhibitory effects of Jatrorrhizine Hydrochloride on metastatic melanoma cell proliferation and neovascularization with low toxicity suggest that Jatrorrhizine Hydrochloride is a potential new antimelanoma drug candidate.
- Molecular Weight: 373.83
- Molecular Formula: C20H20ClNO4
Purity: >98%
Canonical SMILES:
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC.[Cl-]
InChI:
InChI=1S/C20H19NO4.ClH/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3;/h4-5,8-11H,6-7H2,1-3H3;1H
InChIKey: JKMUUZMCSNHBAX-UHFFFAOYSA-N
- Melting Point: 208-210°C
- Solubility: Soluble in Methanol (Slightly, Heated)
- Appearance: Orange Solid
- Storage: Store at -20°C under inert atmosphere
Synonyms:
Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, chloride (1: 1); Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy-, chloride; Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, monochloride; Jatrorrhizine chloride; Neprotine chloride; NSC 645313
More details are to be found on supplier website
