Description:
Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. It is under investigation as a possible treatment for chronic myelogenous leukemia (CML).
- Molecular Weight: 529.52
- Molecular Formula: C28H22F3N7O
Purity: ≥98%
Canonical SMILES:
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
InChI:
InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
InChIKey: HHZIURLSWUIHRB-UHFFFAOYSA-N
- Melting Point: 231-233 °C
- Appearance: Off-White to Pale Yellow Solid
Synonyms:
Tasigna; AMN107; AMN 107; AMN-107; BW 33A, 51W89
More details are to be found on supplier website
