Description:
LH846 is a selective inhibitor of CK1δ, which displays no inhibitory activity at CK2. It inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein, showing to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.
- Molecular Weight: 316.81
- Molecular Formula: C16H13ClN2OS
Purity: >98%
Canonical SMILES:
CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
InChI:
InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
InChIKey: DYHAMRNAHTWYKY-UHFFFAOYSA-N
Synonyms:
LH846; LH 846; LH-846
More details are to be found on supplier website
