Description:
Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation.
- Molecular Weight: 274.192
- Molecular Formula: C13H9NOSe
Purity: >98%
Canonical SMILES:
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChI:
InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChIKey: DYEFUKCXAQOFHX-UHFFFAOYSA-N
- Boiling Point: 402.8±28.0 °C at 760 mmHg
- Melting Point: 178-181 °C
- Solubility: In Vitro: DMSO : 50 mg/mL(182.36 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution2.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution
- Appearance: white solid powder
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
SPI-1005; SPI1005; SPI 1005; Ebselen; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305
More details are to be found on supplier website
