Description:
Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It has the ability to stimulate calcium ion influx into the cardiac cell. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme. It is a drug that may improve the prognosis in patients with congestive heart failure. It has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). It was developed by Sanofi and has been listed.
- Molecular Weight: 187.20
- Molecular Formula: C10H9N3O
Purity: 98%
Canonical SMILES:
C1=CN=CC=C1C2=CNC(=O)C(=C2)N
InChI:
InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChIKey: RNLQIBCLLYYYFJ-UHFFFAOYSA-N
- Boiling Point: 451.5±45.0 °C | Condition: Press: 760 Torr
- Melting Point: 295 °C (decomp)
- Solubility: DMSO (Slightly), Methanol (Slightly)
- Appearance: Pale Beige to Yellow Solid
- Application: Amrinone is a simple, non-glycoside cardiotonic agent. It provides protection against ischemia-reperfusion injury in kidney, liver, and heart. It is used in the treatment of congestive heart failure. It increases cardiac contractility as a vasodilator.
- Storage: 2-8°C
Synonyms:
Inamrinone;Wincoram;Inocor;Cordemcura;Win-40680;Win40680;3-Amino-5-pyridin-4-yl-1H-pyridin-2-one
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