Description:
Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis.
- Molecular Weight: 494.52
- Molecular Formula: C20H22N4O5.CH4O3S
Purity: >98%
Canonical SMILES:
O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
InChI:
1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChIKey: FSEKIHNIDBATFG-UHFFFAOYSA-N
- Boiling Point: 634.6°C at 760 mmHg
- Melting Point: 162-164°C
- Solubility: In Vitro: DMSO : 125 mg/mL(252.77 mM;Need ultrasonic)H2O : ≥ 50 mg/mL(101.11 mM)In Vivo: 1.Add each solvent one by one: PBSSolubility: 12.5 mg/mL (25.28 mM); Clear solution; Need ultrasonic2.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution3.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution4.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution
- Appearance: Solid powder
- Application: Trypsin Inhibitors
- Storage: 4°C, sealed storage, away from moisture* In solvent : -80°C, 6 months-20°C, 1 month (sealed storage, away from moisture)
Synonyms:
4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305
More details are to be found on supplier website
