Description:
Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
- Molecular Weight: 407.57
- Molecular Formula: C21H46NO4P
Purity: >98%
Canonical SMILES:
CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C
InChI:
InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
InChIKey: PQLXHQMOHUQAKB-UHFFFAOYSA-N
- Melting Point: 223-228°C (dec.)
- Solubility: Soluble in Chloroform (Slightly), Methanol (Slightly)
- Appearance: White to Off-white Solid
- Application: Antineoplastic Agents
- Storage: Store at -20°C
Synonyms:
n-hexadecylphosphocholine; Hexadecylphosphocholine; Miltex; Impavido; 2-[[(Hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium; MAPCHO
®-16; C-16Miltefosine
More details are to be found on supplier website
