Description:
Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
- Molecular Weight: 414.684
- Molecular Formula: C16H17BrClN3O3
Purity: > 95%
Canonical SMILES:
C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
InChI:
InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m0/s1
InChIKey: LVASCWIMLIKXLA-LSDHHAIUSA-N
- Boiling Point: 595.8±60.0 °C at 760 mmHg
- Melting Point: >150°C
- Application: semisynthetic quinazolinone alkaloid anticoccidial
- Storage: -20°C
Synonyms:
Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110
More details are to be found on supplier website
