Description:
Nutlin-3 is an MDM2 antagonist, inhibiting p53-Mdm2 interaction (IC50=0.09 µM) via affecting p53 binding pocket of MDM2. It has been studied in anticancer reseaches.
- Molecular Weight: 581.49
- Molecular Formula: C30H30Cl2N4O4
Purity: >98%
Canonical SMILES:
CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI:
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChIKey: BDUHCSBCVGXTJM-UHFFFAOYSA-N
- Solubility: Soluble in DMSO.
- Appearance: White Solid
- Storage: Store at -20°C
Synonyms:
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one; 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
More details are to be found on supplier website
