Description:
Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. It is actively transported into cells by the folate transporter. It is also an impurity of Methotrexate, an antimetabolite and immunosuppressant used in chemotherapy and auto-immune diseases.
- Molecular Weight: 440.41
- Molecular Formula: C19H20N8O5
Purity: > 95%
Canonical SMILES:
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N
InChI:
InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
InChIKey: TVZGACDUOSZQKY-LBPRGKRZSA-N
- Melting Point: >200°C (dec.)
- Appearance: Dark Yellow Solid
Synonyms:
Aminopterin; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; 4-Aminofolic Acid; 4-Aminopteroyl-L-glutamic Acid; 4-Amino-PGA
More details are to be found on supplier website
