Description:
TGN 020 is a derivative of thiadiazole and an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). TGN 020 increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
- Molecular Weight: 206.22
- Molecular Formula: C8H6N4OS
Purity: 98%
Canonical SMILES:
C1=CC(=CN=C1)C(=O)NC2=NN=CS2
InChI:
InChI=1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
InChIKey: AGEGZHOPKZFKBP-UHFFFAOYSA-N
- Melting Point: 289-293°C
- Solubility: In DMSO: 16.67 mg/mL (80.84 mM; Need ultrasonic)
- Appearance: White to Off-White Solid
- Storage: Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
Synonyms:
TGN-020; TGN 020; TGN020; N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide; 2-(Nicotinamido)-1,3,4-thiadiazole
More details are to be found on supplier website
