Description:
BML-277 is a selective APT-competitive inhibitor of the DNA damage response signaling enzyme CHK2 ( IC50 =15 nM).
- Molecular Weight: 363.80
- Molecular Formula: C20H14ClN3O2
Purity: ≥98%
Canonical SMILES:
C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
InChI:
1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChIKey: UXGJAOIJSROTTN-UHFFFAOYSA-N
- Solubility: Soluble in DMSO
- Appearance: Off-white solid
- Application: A selective APT-competitive inhibitor
- Storage: Store at -20 °C
Synonyms:
BML-277; BML 277; BML277; Chk2 Inhibitor II;2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide;
More details are to be found on supplier website
