Description:
Selective transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type-specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle.
- Molecular Weight: 250.34
- Molecular Formula: C17H18N2
Purity: >98%
Canonical SMILES:
CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2
InChI:
InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
InChIKey: LQUNNCQSFFKSSK-UHFFFAOYSA-N
Synonyms:
ZLN005; ZLN-005; ZLN 005.
More details are to be found on supplier website
