Description:
ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form.
- Molecular Weight: 323.8
- Molecular Formula: C17H13N5·HCl
Purity: ≥98%
Canonical SMILES:
CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1
InChI:
InChI=1S/C17H13N5.ClH/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14;/h2-10H,1H3,(H,19,22);1H
InChIKey: ZKLHJSQURWMEIX-UHFFFAOYSA-N
- Solubility: Soluble to 28.73 mg/mL in DMSO, to 5.75 mg/mL in ethanol.
- Appearance: Crystalline Solid
Synonyms:
E 616452; RepSox; SJN 2511
More details are to be found on supplier website
