Description:
Z-Guggulsterone is a broad spectrum steroid receptor ligand that acts as a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki = 37, 224 and 252 nM, respectively) and weak androgen receptor agonist (Ki = 315 nM). Z-Guggulsterone is also a selective antagonist of farnesoid X receptor (FXR) exhibiting antilipidemic, antiseptic, antirheumatic and anti-inflammatory activity in vivo.
- Molecular Weight: 312.45
- Molecular Formula: C21H28O2
Purity: ≥98% by HPLC
Canonical SMILES:
CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI:
InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChIKey: WDXRGPWQVHZTQJ-OSJVMJFVSA-N
- Melting Point: >191°C (dec.)
- Appearance: Off-White Solid
Synonyms:
(Z)-Pregna-4,17(20)-diene-3,16-dione
More details are to be found on supplier website
