Description:
Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures.
- Molecular Weight: 311.29
- Molecular Formula: C16H13N3O4
Purity: ≥98%
Canonical SMILES:
O=C1N([H])C(C2=CC([N+]([O-])=O)=CC=C2)=CCN1C3=CC=CC=C3O
InChI:
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChIKey: RCEFMOGVOYEGJN-UHFFFAOYSA-N
- Solubility: Soluble in DMSO
- Appearance: Yellow-orange solid
- Application: Both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors
- Storage: Store at -20 °C
Synonyms:
AG 3-5; AG3-5; AG-3-5; AG 3-5 cpd; 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one;3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone;
More details are to be found on supplier website
