Description:
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.
- Molecular Weight: 425.5
- Molecular Formula: C19H19NOS.C4H4O4
Purity: >98%
Canonical SMILES:
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI:
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey: YNQQEYBLVYAWNX-WLHGVMLRSA-N
- Boiling Point: 250-263 °C(lit.)
- Melting Point: >191°C (dec.)
- Solubility: In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM)H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: PBSSolubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic2.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution3.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
- Appearance: Off-white crystalline powder
- Application: Antipruritics
- Storage: 4°C, sealed storage, away from moisture* In solvent : -80°C, 6 months-20°C, 1 month (sealed storage, away from moisture)
Synonyms:
Zaditen; Zaditor
More details are to be found on supplier website
