Description:
STAT5-IN-1, a cell-permeable nonpeptidic nicotinoyl hydrazone compound, is a selective STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform with much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50>500 µM).
- Molecular Weight: 293.28
- Molecular Formula: C16H11N3O3
Canonical SMILES:
C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=O)C3=CN=CC=C3
InChI:
1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)/b18-9+
InChIKey: DAVIKTBRCQWOGT-GIJQJNRQSA-N- Melting Point: 214-216 °C
- Solubility: DMSO: ≥23.0 mg/mL
- Storage: Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms:
MDK-6314; STAT5 Inhibitor; STAT5Inhibitor; STAT5-Inhibitor; MDK 6314; MDK6314. N-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide; STAT5 Inhibitor
More details are to be found on supplier website
