Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
Medical and organic intermediates,an important amino protective agent.Pharmaceutical and synthetic organic makes intermediates, organic synthesis used to introduce t-Boc protect gene. Specially used in amino acids amino protection,widely used in pharmaceutical,protein and peptide synthesis, biochemistry food, cosmetics and many other kinds of products of synthesis.
mp 23 °C(lit.)
bp 65-67 °C
density 0.95 g/mL at 25 °C(lit.)
refractive index n20/D 1.409(lit.)
Fp 99 °F
storage temp. 2-8°C
Sensitive Moisture Sensitive
BRN 1911173
Chemical Properties White to off-white microcrystalline powder
Usage Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.
