Description:
Srpin340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 µM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. Srpin340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells.
- Molecular Weight: 349.35
- Molecular Formula: C18H18F3N3O
Purity: 99.82%
Canonical SMILES:
C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3
InChI:
InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChIKey: DWFGGOFPIISJIT-UHFFFAOYSA-N
- Boiling Point: 395.9±42.0 °C at 760 mmHg
- Solubility: In vitro: 10 mM in DMSO
- Appearance: White to light yellow (Solid)
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
SRPIN-340; SRPIN 340
More details are to be found on supplier website
