Description:
GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death.
- Molecular Weight: 348.406
- Molecular Formula: C20H20N4O2
Purity: 98%
Canonical SMILES:
CCC1=C(C(=NC=C1C2=CN=C(C=C2)C(=O)NC)N)C3=CC=C(C=C3)O
InChI:
InChI=1S/C20H20N4O2/c1-3-15-16(13-6-9-17(23-10-13)20(26)22-2)11-24-19(21)18(15)12-4-7-14(25)8-5-12/h4-11,25H,3H2,1-2H3,(H2,21,24)(H,22,26)
InChIKey: UCYSSYGGXOFJKK-UHFFFAOYSA-N
- Solubility: DMSO: ≥ 310 mg/mL (889.78 mM)
Synonyms:
GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide
More details are to be found on supplier website
