Description:
(±)-10-Hydroxycamptothecin is an alkaloid derived from the seed or root bark of the deciduous plant Camptotheca acuminata. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. It exhibits anticancer and antiangiogenic activities. It can be used in cosmetics material.
- Molecular Weight: 364.35
- Molecular Formula: C20H16N2O5
Purity: ≥95%
Canonical SMILES:
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI:
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChIKey: HAWSQZCWOQZXHI-UHFFFAOYSA-N
- Boiling Point: 820.7±65.0°C at 760 mmHg
- Melting Point: 230-237°C
- Solubility: Soluble in DMSO (Slightly), Methanol (Slightly, Heated)
- Appearance: Pale Yellow Powder
- Storage: Store at -20°C under inert atmosphere
Synonyms:
1H-Pyrano[3',4': 6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-; 1H-Pyrano[3',4': 6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (±)-; (+/-)-10-Hydroxycamptothecin; 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4': 6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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