Description:
Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers.
- Molecular Weight: 638.829
- Molecular Formula: C27H31Br2ClN4O2
Purity: > 95%
Canonical SMILES:
C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
InChI:
InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChIKey: DHMTURDWPRKSOA-RUZDIDTESA-N
- Melting Point: 150-152°C
- Solubility: ~3mg/ml
- Appearance: white solid powder
- Application: Enzyme Inhibitors
Synonyms:
SCH 66336; SCH-66336; SCH66336; Sarasar
More details are to be found on supplier website
