Description:
PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner.
- Molecular Weight: 359.26
- Molecular Formula: C14H12F3N3O5
Purity: >98%
Canonical SMILES:
C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
InChI:
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N
- Boiling Point: 462.3±55.0
- Melting Point: >140°C
- Solubility: <1 mg/mL
- Appearance: Solid powder
Synonyms:
PA824; PA-824; PA 824; Pretomanid.
More details are to be found on supplier website
