Description:
Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 = 20 nM), DiFi humancolon cancer cells and MDA MB-468 human breast cancer cells.
- Molecular Weight: 429.90
- Molecular Formula: C22H23N3O4.HCl
Purity: >98%
Canonical SMILES:
COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
InChI:
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChIKey: GTTBEUCJPZQMDZ-UHFFFAOYSA-N
- Boiling Point: 553.6°C at 760 mmHg
- Melting Point: 223-225°C
- Solubility: Soluble in Acetic Acid, Dimethylformamide, Dimethyl Sulfoxide, Methanol
- Appearance: Off-white Solid
- Application: Antineoplastic Agents
- Storage: Store at 2-8°C
Synonyms:
OSI-744; OSI744; OSI 744; Tarceva; 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride; 6,7-bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
More details are to be found on supplier website
