Description:
Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways.
- Molecular Weight: 529.652
- Molecular Formula: C27H35N3O6S
Canonical SMILES:
CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)C(=O)OCC)N
InChI:
InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChIKey: GWEJFLVSOGNLSS-WPFOTENUSA-N- Boiling Point: 749.7±60.0°C(Predicted)
- Melting Point: >94°C (dec.)
- Appearance: White Solid
- Storage: Store at -20°C
Synonyms:
Telintra; Gamma-Glu-S-BzCys-PhGly diethyl ester; TLK-199; TLK 199
More details are to be found on supplier website
