Description:
Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
- Molecular Weight: 288.2
- Molecular Formula: C11H14ClN5·HCl
Purity: ≥95%
Canonical SMILES:
CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl
InChI:
InChI=1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
InChIKey: MOUAPRKJJUXEIE-UHFFFAOYSA-N
- Appearance: Crystalline Solid
- Application: Antimalarials
Synonyms:
Chloroguanide Triazine; NSC 3074; 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride
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