CAS No. 1448189-80-7

Molecular Formula: C22H31ClN4O3S
Molecular Weight: 467.02454

Description:
Protein degrader 1 hydrochloride is a building block used in the synthesis of PROTAC for the recruitment of the von Hippel-Lindau (VHL) protein.

• Molecular Weight: 467.02
• Molecular Formula: C22H31ClN4O3S

Purity: ≥98%

Canonical SMILES:
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O.Cl

InChI:
InChI=1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17+,19-;/m1./s1

InChIKey: JYRTWGCWUBURGU-MSSRUXLCSA-N

• Solubility: 10 mM in DMSO.
• Storage: -20°C

Synonyms:
(S,R,S)-AHPC hydrochloride; (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

More details are to be found on supplier website

Mol Weight: 430,56 (free base) g/mol

More details are to be found on supplier website

Acting as a reagent in the synthesis of PROTAC compounds, which mediate the degradation of c-ABL and BCR-ABL that cause cancer.

Smile code:
O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
MDL Number:
MFCD30502992
Purity :
98%
Available in stock:
10.2 g