Description:
Tenofovir alafenamide hemifumarate, also known as Tenofovir alafenamide fumarate (2: 1), is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevents HIV from multiplying and can reduce the amount of HIV in the body.
- Molecular Weight: 1069.02
- Molecular Formula: C46H62N12O14P2
Purity: > 98%
Canonical SMILES:
CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C1N=CN=C2N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C1N=CN=C2N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O
InChI:
InChI=1S/2C21H29N6O5P.C4H4O4/c2*1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;5-3(6)1-2-4(7)8/h2*5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*15-,16+,33+;/m11./s1
InChIKey: SVUJNSGGPUCLQZ-FQQAACOVSA-N
- Solubility: In Vitro: DMSO: 50 mg/mLH2O: 20 mg/mLIn Vivo: 1.Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% salineSolubility: ≥ 2.5 mg/mL (4.68 mM)2.Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)Solubility: 2.5 mg/mL (4.68 mM)3.Add each solvent one by one: 10% DMSO >> 90% corn oil salineSolubility: ≥ 2.5 mg/mL (4.68 mM)
- Appearance: White to Off-White Solid
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate; TAF; GS734; GS-734; GS 734; GS 7340; GS-7340; GS7340; Tenofovir alafenamide fumarate (2: 1)
More details are to be found on supplier website
