Description:
RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition.
- Molecular Weight: 326.374
- Molecular Formula: C16H14N4O2S
Purity: >98%
Canonical SMILES:
C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3
InChI:
InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey: GDVRVPIXWXOKQO-UHFFFAOYSA-N
- Melting Point: >205°C (dec.)
- Appearance: Pale Yellow Solid
Synonyms:
RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
More details are to be found on supplier website
