Description:
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.
- Molecular Weight: 540.69
- Molecular Formula: C24H36N4O6S2
Purity: >98%
Canonical SMILES:
CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
InChI:
InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
InChIKey: OHRURASPPZQGQM-GCCNXGTGSA-N
- Boiling Point: 942.8°C at 760 mmHg
- Melting Point: 235-245°C
- Solubility: Soluble in Chloroform, DMSO (10 mg/ml at 25°C), Ethanol (<1 mg/ml at 25°C), Methanol, Water (<1 mg/ml at 25°C)
- Appearance: White to Off-white Powder
- Application: For research used only
- Storage: Store at -20°C
Synonyms:
Istodax; FK228; FK 228; FK-228; Chromadax; Antibiotic FR 901228; FR901228; FR-901228; NSC-630176; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
More details are to be found on supplier website
