Description:
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent.
- Molecular Weight: 806.957
- Molecular Formula: C42H56F2N8O6
Purity: >99.50%
Canonical SMILES:
CCC(C(=O)N1CC(CC1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)CC6CC(CN6C(=O)C(CC)NC(=O)C(C)NC)O)O)NC(=O)C(C)NC
InChI:
InChI=1S/C42H56F2N8O6/c1-7-33(49-39(55)21(3)45-5)41(57)51-19-27(53)15-25(51)17-31-29-11-9-23(43)13-35(29)47-37(31)38-32(30-12-10-24(44)14-36(30)48-38)18-26-16-28(54)20-52(26)42(58)34(8-2)50-40(56)22(4)46-6/h9-14,21-22,25-28,33-34,45-48,53-54H,7-8,15-20H2,1-6H3,(H,49,55)(H,50,56)/t21-,22-,25-,26-,27-,28-,33-,34-/m0/s1
InChIKey: PKWRMUKBEYJEIX-DXXQBUJASA-N
- Boiling Point: 1090.5±65.0 °C at 760 mmHg
- Solubility: In Vitro: DMSO : 125 mg/mL(154.91 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution2.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: 2.08 mg/mL (2.58 mM); Suspended solution; Need ultrasonic3.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.08 mg/mL (2.58 mM); Clear solution
- Appearance: white solid powder
- Storage: Powder: -20°C 3 years4°C 2 yearsIn solvent: -80°C 6 months-20°C 1 months
Synonyms:
TL-32711; TL32711; TL 32711. Birinapant
More details are to be found on supplier website
