Description:
Loureirin B, isolated from the herbs of Dracaena cochinchinensis, is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B might be the cellular and molecular basis of SD-mediated immunosuppression. Loureirin B could evoke the elevation of [Ca(2+)](i) in a dose-dependent manner. Loureirin B is also the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons.
- Molecular Weight: 316.35
- Molecular Formula: C18H20O5
Purity: >98%
Canonical SMILES:
COC1=CC(=C(C(=C1)OC)CCC(=O)C2=CC=C(C=C2)O)OC
InChI:
InChI=1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3
InChIKey: ZPFRAPVRYLGYEC-UHFFFAOYSA-N
- Appearance: White powder
- Application: Analgesic/anti-inflammatory
Synonyms:
1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl)
More details are to be found on supplier website
