Description:
J 147, under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, is a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer's disease mouse model.in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 - 200 nM)in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus
- Molecular Weight: 350.33
- Molecular Formula: C18H17F3N2O2
Canonical SMILES:
CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C
InChI:
1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
InChIKey: HYMZAYGFKNNHDN-SSDVNMTOSA-N- Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
- Appearance: White solid
- Application: Implicated in Alzheimer's disease
- Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -37°C for long term (months to years).
Synonyms:
J147; J 147; J-147. N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide; J-147; 1146963-51-0; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide; J 147|2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
More details are to be found on supplier website
