Description:
PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea.
- Molecular Weight: 409.41
- Molecular Formula: C23H20FNO5
Purity: 98%
Canonical SMILES:
COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O
InChI:
InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChIKey: LWJGMYMNSNVCEM-UHFFFAOYSA-N
- Solubility: DMSO: 81mg/mL(197.84mM); Water: <1mg/mL(<1mM); Ethanol: <1mg/mL(<1mM)
- Appearance: White Solid
- Storage: 3 years -20°C powder; 6 months -80°C in solvent
Synonyms:
PF04418948; PF-04418948; PF 04418948; PF4418948; PF-4418948; PF 4418948.
More details are to be found on supplier website
