Description:
JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials.
- Molecular Weight: 472.32
- Molecular Formula: C23H19Cl2N3O
Purity: >98 %
Canonical SMILES:
C1=CC=C(C=C1)C2=NC3=C(O2)C(=CC(=C3)N)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl
InChI:
InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
InChIKey: XNRZJPQTMQZBCE-SFHVURJKSA-N
- Boiling Point: 672.0±55.0 °C | Condition: Press: 760 Torr
- Solubility: Slightly soluble in DMSO, not soluble in water. Soluble in 5% hydrochloride
- Appearance: White to off-white solid powder
- Application: JPH203 suppresses proliferation in cancer cell lines and is used for cancer research.
- Storage: -20°C Freezer
Synonyms:
KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid
More details are to be found on supplier website
