Description:
Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
- Molecular Weight: 776.028
- Molecular Formula: C40H53N7O5S2
Purity: 0.99
Canonical SMILES:
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
InChI:
InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
InChIKey: ZCIGNRJZKPOIKD-CQXVEOKZSA-N
- Boiling Point: 974.5±65.0 °C at 760 mmHg
- Melting Point: 87-105°C
- Solubility: In Vitro: DMSO : 250 mg/mL(322.16 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution2.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution3.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution
- Appearance: off-white solid
- Application: Anti-HIV Agents
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
Cobicistat, GS-9350; GS 9350; GS9350
More details are to be found on supplier website
