Description:
Tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia.
- Molecular Weight:300.26
- Boiling Point:601.5±55.0 °C at 760 mmHg
- Melting Point:225-226°C
- Purity:>98%
Molecular Formula:
C16H12O6
Canonical SMILES:
COC1=C(C2=C(C=C1O)OC=C(C2=O)C3=CC=C(C=C3)O)O
InChI:
InChI=1S/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3
InChIKey:
OBBCRPUNCUPUOS-UHFFFAOYSA-N
Solubility:
Soluble in DMSO
Appearance:
White to Orange to Green Powder to Crystal
Application:
Antioxidant.
Storage: Store at 2-8°C
Synonyms:
5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 6-Methoxy-5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-; Isoflavone, 4',5,7-trihydroxy-6-methoxy-; 5,7,4'-Trihydroxy-6-methoxyisoflavone; K 251T; Tectrigenin Más detalles se encuentran
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