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Suppliers for CAS
1345847-93-9
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Properties | CAS |
1345847-93-9 | Formula |
C26H21F3N4O4 |
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3 Registered suppliers
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C26H21F3N4O4 Molecular Weight: 510.4645496
Aea.ltd
P.R.China
Molecular Formula: C26H21F3N4O4 Molecular Weight: 510.4645496
BOC Sciences
USA
Description : Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. DCC-2701 may be superior to HGF antagonists that are in clinical trials and that pTyr(1349) levels might be a good indicator of c-MET activation and likely response to targeted therapy as a result of signals from the microenvironment. - Molecular Weight :510.46
- Purity :> 98%
Molecular Formula : C26H21F3N4O4 Canonical SMILES : C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F InChI : InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34) InChIKey : GNNDEPIMDAZHRQ-UHFFFAOYSA-N Synonyms : DCC2701; DCC 2701; DCC-2701; DP 5164; DP5164; DP-5164; Altiratinib.
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Last update 2024-05-26
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