BGC > CAS Search > 1236208-20-0

Molecular Formula: C18H27N3O6S3
Molecular Weight: 477.61848

Molecular Formula: C18H27N3O6S3
Molecular Weight: 477.61848

Description :
TRX-0237 mesylate is a second-generation tau protein aggregation inhibitor applicated for the treatment of AD (Alzheimer's disease) and frontotemporal dementia. TRX-0237 is the purified form of Methylene Blue, an old drug that has being widely used in Africa for the treatment of malaria, methemoglobinemia and other conditions for a long time. TRX-0237 is the stabilized, reduced form of methylthioninium chloride to improve the drug's absorption, bioavailability, and tolerability. TRX-0237 is in Phase I for Parkinson's disease, Phase II for Progressive supranuclear palsy and Phase III for Alzheimer's disease and Dementia.

• Molecular Weight :477.6
• Purity :98%

Molecular Formula :
C18H27N3O6S3
Canonical SMILES :
CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
InChI :
InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)
InChIKey :
SPCMQFLNOVTUBM-UHFFFAOYSA-N
Solubility :
Soluble to 31 mg/mL in water
Appearance :
Powder
Application :
Parkinson's disease; Progressive supranuclear palsy; Alzheimer's disease; Dementia
Storage : -20°C Freezer
Synonyms :
TRX-0237 mesylate; TRX 0237 mesylate; TRX0237 mesylate; Leucomethylene blue (Mesylate); AKOS026750731; CS-5553; AK-499443; HY-19948; CS 5553; AK 499443; HY 19948; CS5553; AK499443; HY19948; N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dimethanesulfonate

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