Description:
AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth.
- Molecular Weight:494.50
- Boiling Point:716.0±70.0 °C(Predicted)
- Purity:≥98%
Molecular Formula:
C24H24F2N8O2
Canonical SMILES:
O=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[C@H](COC)N1CC5=CC=C(F)C(F)=C5
InChI:
InChI=1S/C24H24F2N8O2/c1-14-9-27-24(30-20-6-7-28-32(20)2)31-21(14)19-12-33-11-16(13-36-3)34(23(35)22(33)29-19)10-15-4-5-17(25)18(26)8-15/h4-9,12,16H,10-11,13H2,1-3H3,(H,27,30,31)/t16-/m1/s1
InChIKey:
HVIGNZUDBVLTLU-MRXNPFEDSA-N
Solubility:
Soluble to 202.22 mM in DMSO.
Appearance:
Solid Powder
Synonyms:
AZD-0364; AZD 0364; tizaterkib Más detalles se encuentran
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