BGC > Buscar Producto > 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide | 747412-49-3

Molecular Formula: C26H31N3O5
Molecular Weight: 465.547

Description:
Luminespib, also known as AUY-922 (or NVP-AUY922), is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins.

• Molecular Weight:465.54
• Boiling Point:640.1±55.0 °C at 760 mmHg
• Purity:>98%

Molecular Formula:
C26H31N3O5
Canonical SMILES:
CCNC(=O)C1=C(C(=C2C=C(C(=CC2=O)O)C(C)C)ON1)C3=CC=C(C=C3)CN4CCOCC4
InChI:
InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,28,30H,4,9-12,15H2,1-3H3,(H,27,32)/b25-20-
InChIKey:
SWDZPNJZKUGIIH-QQTULTPQSA-N
Solubility:
DMSO:37 mg/mL
Appearance:
Solid powder
Storage: 3 years -20oC powder, 6 months-80oC in solvent.
Synonyms:
Luminespib; AUY-922; AUY922; AUY 922; NVP-AUY-922; NVP-AUY922; VER-52296; VER52296; VER 52296;