BGC > Produktsuche > JNJ 26854165 | 881202-45-5

Molecular Formula: C21H20N4
Molecular Weight: 328.42
HS Code: 29339900

Description:
Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival.

• Molecular Weight:328.42
• Purity:>98%

Molecular Formula:
C21H20N4
Canonical SMILES:
C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
InChI:
InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKey:
CEGSUKYESLWKJP-UHFFFAOYSA-N
Appearance:
white solid powder
Synonyms:
JNJ-26854165; JNJ26854165; JNJ 26854165