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Suppliers for CAS
881202-45-5
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Properties | | CAS |
881202-45-5 | | Formula |
C21H20N4 |
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5 Registered suppliers
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C21H20N4
Molecular Weight: 328.42
HS Code: 29339900
Aea.ltd
P.R.China
Molecular Formula: C21H20N4
Molecular Weight: 328.42
HS Code: 29339900
BOC Sciences
USA
Description : Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival. - Molecular Weight :328.42
- Purity :> 98%
Molecular Formula : C21H20N4 Canonical SMILES : C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4 InChI : InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKey :
CEGSUKYESLWKJP-UHFFFAOYSA-N
Appearance :
white solid powder
Synonyms :
JNJ-26854165; JNJ26854165; JNJ 26854165
More details are to be found here
Chemos GmbH & Co. KG
Germany
Description : Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival. - Molecular Weight :328.42
- Purity :> 98%
Molecular Formula : C21H20N4 Canonical SMILES : C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4 InChI : InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKey :
CEGSUKYESLWKJP-UHFFFAOYSA-N
Appearance :
white solid powder
Synonyms :
JNJ-26854165; JNJ26854165; JNJ 26854165
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
Description : Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2-p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, this oncoprotein has been implicated in cancer cell proliferation and survival. - Molecular Weight :328.42
- Purity :> 98%
Molecular Formula : C21H20N4 Canonical SMILES : C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4 InChI : InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKey :
CEGSUKYESLWKJP-UHFFFAOYSA-N
Appearance :
white solid powder
Synonyms :
JNJ-26854165; JNJ26854165; JNJ 26854165
More details are to be found here
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details
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