Description:
RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner.
Molecular Formula:
C19H23N3O
Canonical SMILES:
CC(C)OC1=CC=C(C=C1)CC2=CC=C(C=C2)NC3=NCCN3
InChI:
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChIKey:
GYYRMJMXXLJZAB-UHFFFAOYSA-N
Synonyms:
RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine Más detalles se encuentran
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